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Estrogen. When you've got PCOS, your levels of estrogen may very well be too high in relation on your progesterone amounts.Metformin—an insulin-sensitizing agent—may be used alone9 or with clomiphene when clomiphene alone is not really effective to spur or control ovulation in Females with PCOS.2,3Spironolactone can also lead to abdomen upset a